Aspirin lowers risk of early death for patients with diabetes, heart failure

For people living with both Type 2 diabetes and heart failure, taking an aspirin each day appears to lower the risk of dying or being hospitalized for heart failure, according to new research. But the data also reveal aspirin use may increase the risk of nonfatal heart attack or stroke, a somewhat contradictory finding that surprised researchers | American College of Cardiology | via ScienceDaily

The study is the first to assess aspirin as a preventive measure for patients who have both diabetes and heart failure.  drug-1674890_1280

Using data from a United Kingdom database known as The Health Improvement Network (THIN), researchers extracted health records of more than 12,000 patients ages 55 and older who had Type 2 diabetes and heart failure but no prior history of heart attack, stroke, peripheral artery disease or atrial fibrillation. Roughly half had been prescribed daily aspirin and half had not.

Researchers analyzed health outcomes over an average of five years of follow-up. All-cause mortality and hospitalization for heart failure were tracked as a composite primary outcome. All-cause mortality, hospitalization for heart failure, major bleeding events and nonfatal heart attack or stroke were tracked separately as secondary outcomes. Those taking a daily aspirin were found to show a 10 percent decrease in the primary outcome, no difference in major bleeding events, and a 50 percent increase in nonfatal heart attack or stroke.

The research is limited in that it was based on a retrospective analysis of health records, rather than a randomized controlled trial. Further studies would help to confirm the findings, further elucidate the risks and benefits of aspirin use in this patient population, and potentially inform specific guidelines for treatment of patients with diabetes and heart failure.

Full story at ScienceDaily

Research: Can Aspirin Reduce Risk of Death in Patients With Diabetes, HF? | American College of Cardiology

Increased risk of coronary artery disease for females with type 1 diabetes, according to Swedish study

Diabetes patients, who were diagnosed over three decades ago, were studied by scientists in Sweden. They found that females with type 1 diabetes may be at an increased risk of developing coronary artery disease.  (via Science Daily)


The American Journal Diabetes Care has published an article based on the study, which analysed the the extent of coronary artery disease with coronary angiography in people with type 1 diabetes, most of which were conducted in the 1970s, 80s and 90s on seriously ill patients, revealing extensive constrictions of the coronary artery.

The researchers at Karolinska Institutet, Gothenburg University and Uppsala University conducted a large-scale study including all patients in Sweden — just short of 2,800 in number — with type 1 diabetes who had undergone coronary angiography between 2001 and 2013.  This sample comprised ,776 patients (42% women) with mean age 58 years (SD 11) were followed for 7.2 years (SD 2.2) The patients,  had had diabetes for an average of 35 years and had a mean age of 58. One fifth of the patients had normal coronary arteries, one fifth had one constricted artery, and about half had more than one.

 Viveca Ritsinger,  researcher at the Department of Medicine at Karolinska Institutet in Solna, expressed surprise at the findings, “we’d thought that more of the patients would have had extensive coronary artery disease after such a long time with diabetes, but one reason is the ongoing diabetes care we have in Sweden, whereby we’re better able to maintain normal sugar levels soon after disease onset and closely monitor other risk factors for cardiovascular disease.”

She also noted,  “generally speaking women develop coronary artery disease later and less extensively than men. Women with type 2 diabetes can, however, become afflicted earlier than women without diabetes. Our findings suggest that this also applies to women with type 1 diabetes.” (Science Daily)